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— free, 24/7 — free, 24/7| Dosage | Package | Price per Dose | Price | |
|---|---|---|---|---|
| 2,5 mg | 270 pills | $1.05 | $406.59 $284.62 Best Price Popular | |
| 2,5 mg | 180 pills | $1.28 | $328.78 $230.15 | |
| 2,5mg | 120 pills | $1.76 | $301.17 $210.82 | |
| 2,5mg | 90 pills | $2.28 | $293.64 $205.55 | |
| 2,5mg | 60 pills | $2.64 | $225.87 $158.11 | |
| 2,5mg | 30 pills | $2.93 | $125.47 $87.83 | |
| 2,5mg | 10 pills | $3.51 | $50.17 $35.12 |
Letrozole is an aromatase inhibitor that reduces estrogen synthesis by blocking the aromatase enzyme. Its primary use is in treating hormone receptor–positive breast cancer in postmenopausal women.
Letrozole is a prescription medicine used in cancer treatment. It belongs to the class of aromatase inhibitors and acts by blocking the conversion of androgens to estrogens in peripheral tissues, lowering estrogen levels.
Because estrogen can fuel some breast cancers, lowering its level helps slow disease progression. The medicine is taken by mouth as tablets and is typically part of a systemic, long‑term treatment plan.
In postmenopausal women, letrozole is used to treat hormone receptor–positive breast cancer after surgery or radiation, and to manage advanced disease when it has spread.
It may be prescribed as adjuvant therapy to reduce recurrence risk, sometimes replacing or following tamoxifen. In metastatic settings, it aims to slow tumor growth and ease symptoms, often in combination with other systemic treatments as directed by a clinician.
Contraindications: Letrozole should not be used during pregnancy or breastfeeding because of potential harm to the fetus or infant. It is also contraindicated in individuals with a known hypersensitivity to letrozole or any tablet component. In addition, it is not suitable for most premenopausal women, since it works best after ovarian estrogen production is reduced.
Precautions: Do not use estrogens or estrogen‑containing therapies with letrozole, as these can counteract its effects. A clinician will monitor bone density, lipid levels, liver function, and blood counts during treatment. Because letrozole lowers estrogen, long‑term use may affect bone health and cholesterol balance; regular screening and preventive measures for osteoporosis are often advised. Use with caution in liver impairment and discuss any existing liver or kidney conditions with a healthcare provider.
Common side effects (more than 1 in 10 people) include hot flashes, night sweats, joint or muscle pain, fatigue, headache, nausea, and mild hair thinning. Some people may notice dizziness, sleep disturbances, or reduced appetite during therapy.
Less common and rare effects (between 1 in 100 and 1 in 1,000, or less) include elevated blood pressure, lipid changes, significant bone thinning, liver enzyme elevations, rash or hives, or rare liver injury. Mood changes, memory concerns, or allergic reactions can occur, though these are uncommon; seek medical advice if symptoms are severe or persistent.
Interactions with other medicines can affect how letrozole works. Tamoxifen and other selective estrogen receptor modulators can counteract letrozole’s activity when used together, so clinicians may adjust sequencing or choices of therapy. Letrozole is broken down by liver enzymes, so strong CYP3A4 inducers or inhibitors can alter drug levels.
Other potential interactions include estrogen‑containing therapies, fertility drugs, and certain herbal supplements such as St. John’s wort. Always tell a clinician about all prescription and over‑the‑counter medicines, vitamins, and supplements to check for interactions and to adjust treatment as needed.
14–21 days. Free from $200.00 .
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